Supramolecular hydrogels based on antimycobacterial amphiphiles

被引：10

作者：

Bernet, Andreas ^{[1
]}

Behr, Marina ^{[1
]}

Schmidt, Hans-Werner ^{[1
]}

机构：

[1] Univ Bayreuth, BIMF, BZKG, D-95440 Bayreuth, Germany

来源：

SOFT MATTER | 2012年 / 8卷 / 18期

关键词：

DRUG-DELIVERY; RELEASE; MOLECULES; PH; TUBERCULOSIS; DERIVATIVES; ENTRAPMENT; MICELLES; ACID;

D O I：

10.1039/c2sm07456g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Synthetic modification of antimycobacterial 4-alkoxy-anilines yields low molecular weight amphiphiles. The bioactivity is retained in these amphiphiles and shows alkyl chain length specificity. The self-assembly behaviour in aqueous media was investigated. It was found that several of these new compounds are capable of forming thermoreversible supramolecular hydrogels in alkaline aqueous media. The initial drug can be released from the hydrogel by thermal hydrolysis.

引用

页码：4873 / 4876

页数：4

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