Perimenopause and Cognition

被引：80
作者：
Greendale, Gail A. [1 ]
Derby, Carol A. [2 ]
Maki, Pauline M. [3 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA
[2] Albert Einstein Coll Med, Dept Neurol, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
[3] Univ Illinois, Coll Med, Dept Psychiat & Psychol, Ctr Cognit Med, Chicago, IL 60612 USA
来源：
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA | 2011年 / 38卷 / 03期
关键词：
Perimenopause; Menopause; Estrogen; Follicle-stimulating hormone; Cognitive function; Cardiovascular risk factors; Ovariectomy; CONJUGATED EQUINE ESTROGENS; POSTMENOPAUSAL WOMEN EVIDENCE; CARDIOVASCULAR RISK-FACTORS; WHITE-MATTER LESIONS; MENOPAUSAL TRANSITION; HORMONE-THERAPY; VERBAL MEMORY; ALZHEIMERS-DISEASE; CORTISOL-LEVELS; HOT FLASHES;
D O I：
10.1016/j.ogc.2011.05.007
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The impact of perimenopause on cognition seems to be characterized by an absence of improved scores rather than a decline. In the SWAN, the perimenopausal decrement in cognitive performance was not accounted for; however, increases in anxiety and depressive symptoms had independent, unfavorable effects on performance. Estradiol has been found to protect against changes resulting from serotonin withdrawal and defend against changes from cholinergic depletion. There is support for the critical timing hypothesis that estrogen benefits cognitive function when instituted early, but not later. The menopausal transition may affect cognitive function in older age owing to worsened cardiovascular risk factors.
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页码：519 / +
页数：18
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