Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis

被引:7
作者
Gao, RuiJiao [1 ]
Lv, Ying [2 ]
机构
[1] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Dept Ancient Tradit Chinese Med, Guangzhou 510610, Peoples R China
关键词
RHIZOMA;
D O I
10.1155/2022/9061752
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Colorectal cancer (CRC) is the third most diagnosed cancer worldwide and is a significant cause of cancer-related deaths. Previous studies have observed that Coptis chinensis (CC) and Mume Fructus (MF) are effective against CRC, enteritis, and intestinal dysbiosis, but the chemical and pharmacological mechanisms remain poorly understood. In this study, we employed pharmacological network analysis to reveal mechanisms underlying the therapeutic effect of CC and MF against CRC. All compounds and targeted genes were obtained from the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP). Differentially expressed genes (DEGs) were identified based on GSE146587, GSE156720, and GSE184093 datasets. A protein-protein interaction (PPI) network was constructed to identify putative target genes of CC and MF. Ten key targeted genes were identified, including CCND1, ICAM1, IL1B, IL-6, MMP1, MMP3, MMP9, MYC, SERPINE1, and VEGFA. Among these genes, six (ICAM1, IL1B, IL-6, MMP1, MMP3, MMP9, and SERPINE1) were positively correlated with levels of effector memory CD4 T cells and natural killer T cells, and three (CCND1, MYC, and VEGFA) were negatively correlated with type 17 T helper cells and CD56dim natural killer cells. Molecular docking analysis showed that four compounds of CC and MF (kaempferol, oleanolic acid, quercetin, and ursolic acid) could affect CRC by interacting with target genes. Our study proved that pharmacological analysis could reliably assess the mechanism of traditional Chinese medicines for treating cancer.
引用
收藏
页数:14
相关论文
共 65 条
  • [1] Cruciferous Vegetables and Their Bioactive Metabolites: from Prevention to Novel Therapies of Colorectal Cancer
    Agaguenduez, Duygu
    Sahin, Teslime Oezge
    Yilmaz, Birsen
    Ekenci, Kuebra Damla
    Duyar oezer, Sehriban
    Capasso, Raffaele
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [2] Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects
    Ahmed, Salman
    Khan, Haroon
    Aschner, Michael
    Mirzae, Hamed
    Akkol, Esra Kupeli
    Capasso, Raffaele
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (16) : 1 - 20
  • [3] Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
    Akkol, Esra Kupeli
    Tatli, Iffet Irem
    Karatoprak, Gokce Seker
    Agar, Osman Tuncay
    Yucel, Cigdem
    Sobarzo-Sanchez, Eduardo
    Capasso, Raffaele
    [J]. CANCERS, 2021, 13 (11)
  • [4] Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer
    Akkol, Esra Kupeli
    Genc, Yasin
    Karpuz, Busra
    Sobarzo-Sanchez, Eduardo
    Capasso, Raffaele
    [J]. CANCERS, 2020, 12 (07) : 1 - 25
  • [5] Biomarkers in Colorectal Cancer: The Role of Translational Proteomics Research
    Alves Martins, Bruno Augusto
    de Bulhoes, Gabriel Fonseca
    Cavalcanti, Igor Norat
    Martins, Mickaella Michelson
    de Oliveira, Paulo Goncalves
    Araujo Martins, Aline Maria
    [J]. FRONTIERS IN ONCOLOGY, 2019, 9
  • [6] Natural products as aromatase inhibitors
    Balunas, Marcy J.
    Su, Bin
    Brueggemeier, Robert W.
    Kinghorn, A. Douglas
    [J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2008, 8 (06) : 646 - 682
  • [7] Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    Barbie, David A.
    Tamayo, Pablo
    Boehm, Jesse S.
    Kim, So Young
    Moody, Susan E.
    Dunn, Ian F.
    Schinzel, Anna C.
    Sandy, Peter
    Meylan, Etienne
    Scholl, Claudia
    Froehling, Stefan
    Chan, Edmond M.
    Sos, Martin L.
    Michel, Kathrin
    Mermel, Craig
    Silver, Serena J.
    Weir, Barbara A.
    Reiling, Jan H.
    Sheng, Qing
    Gupta, Piyush B.
    Wadlow, Raymond C.
    Le, Hanh
    Hoersch, Sebastian
    Wittner, Ben S.
    Ramaswamy, Sridhar
    Livingston, David M.
    Sabatini, David M.
    Meyerson, Matthew
    Thomas, Roman K.
    Lander, Eric S.
    Mesirov, Jill P.
    Root, David E.
    Gilliland, D. Gary
    Jacks, Tyler
    Hahn, William C.
    [J]. NATURE, 2009, 462 (7269) : 108 - U122
  • [8] Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura
    Bari, Md Sazzadul
    Khandokar, Labony
    Haque, Ehfazul
    Romano, Barbara
    Capasso, Raffaele
    Seidel, Veronique
    Haque, Md Areeful
    Rashid, Mohammad Abdur
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2021, 271
  • [9] Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches
    Bristy, Tahmina Akter
    Barua, Niloy
    Tareq, Abu Montakim
    Sakib, Shahenur Alam
    Etu, Saida Tasnim
    Chowdhury, Kamrul Hasan
    Jyoti, Mifta Ahmed
    Ibn Aziz, Md Arfin
    Reza, A. S. M. Ali
    Caiazzo, Elisabetta
    Romano, Barbara
    Tareq, Syed Mohammed
    Bin Emran, Talha
    Capasso, Raffaele
    [J]. PHARMACEUTICALS, 2020, 13 (08) : 1 - 24
  • [10] Burley SK, 2017, METHODS MOL BIOL, V1606, P627, DOI 10.1007/978-1-4939-7000-1_26