Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine-coumarin hybrids

被引：41

作者：

Goel, Richa ^{[1
]}

Luxami, Vijay ^{[1
]}

Paul, Kamaldeep ^{[1
]}

机构：

[1] Thapar Univ, Sch Chem & Biochem, Patiala 147001, Punjab, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 47期

关键词：

NATIONAL-CANCER-INSTITUTE; DRUG DISCOVERY; DESIGN; DERIVATIVES; INHIBITORS; KINASE; PYRAZINES; POTENT;

D O I：

10.1039/c5ra00584a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of imidazo[1,2-a]pyrazine-coumarin hybrids have been synthesized by the combination of two biologically active moieties, imidazo[1,2-a]pyrazine and coumarin, followed by the Suzuki-Miyaura cross coupling reaction for monoarylation at the C6 position and symmetrical/unsymmetrical diarylation at the C3 and C6 positions. These compounds were further screened for their in vitro antitumor activities.

引用

页码：37887 / 37895

页数：9

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