Apoptosis of lymphocytes in mice administered lipopolysaccharide from Leptospira interrogans

被引：13

作者：

Isogai, E ^{[1
]}

Isogai, H ^{[1
]}

Kubota, T ^{[1
]}

Fujii, N ^{[1
]}

Hayashi, S ^{[1
]}

Indoh, T ^{[1
]}

Takagi, S ^{[1
]}

Miura, H ^{[1
]}

Kimura, K ^{[1
]}

机构：

[1] Hlth Sci Univ Hokkaido, Dept Prevent Dent, Ishikari, Hokkaido 06102, Japan

来源：

JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH | 1998年 / 45卷 / 09期

关键词：

D O I：

10.1111/j.1439-0450.1998.tb00824.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We report that administration of leptospiral lipopolysaccharide (LPS) in mice results in massive surface marker changes in the lymphocytes of the spleen. It appears that many of these changes relate to the large number of cells undergoing apoptosis. It is also shown that tumor necrosis factor-alpha (TNF-alpha) induces similar effects and is produced in large quantities after injection of leptospiral LPS. It is likely that cytokines such as TNF-alpha are involved in apoptosis.

引用

页码：529 / 537

页数：9

共 28 条

[1]

[Anonymous], 1994, LEPTOSPIRA LEPTOSPIR

[2] COMING TO TERMS WITH DEATH - APOPTOSIS IN CANCER AND IMMUNE DEVELOPMENT [J].

ASHWELL, JD ;

BERGER, NA ;

CIDLOWSKI, JA ;

LANE, DP ;

KORSMEYER, SJ .

IMMUNOLOGY TODAY, 1994, 15 (04) :147-151

[3]

BAUGEN RE, 1996, MICROORGANISMS AUTOI, P79

[4]

GRELL M, 1994, J IMMUNOL, V153, P1963

[5] A NATURAL MODEL OF IMMUNOLOGICAL-TOLERANCE - TOLERANCE TO MURINE-C5 IS MEDIATED BY T-CELLS, AND ANTIGEN IS REQUIRED TO MAINTAIN UNRESPONSIVENESS [J].

HARRIS, DE ;

CAIRNS, L ;

ROSEN, FS ;

BOREL, Y .

JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 156 (02) :567-584

[6] ELIMINATION FROM PERIPHERAL LYMPHOID-TISSUES OF SELF-REACTIVE LYMPHOCYTES-B RECOGNIZING MEMBRANE-BOUND ANTIGENS [J].

HARTLEY, SB ;

CROSBIE, J ;

BRINK, R ;

KANTOR, AB ;

BASTEN, A ;

GOODNOW, CC .

NATURE, 1991, 353 (6346) :765-769

[7]

ISOGAI E, 1990, ZBL BAKT-INT J MED M, V273, P200

[8] BIOLOGICAL-ACTIVITIES OF LEPTOSPIRAL LIPOPOLYSACCHARIDE [J].

ISOGAI, E ;

ISOGAI, H ;

KUREBAYASHI, Y ;

ITO, N .

ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIES A-MEDICAL MICROBIOLOGY INFECTIOUS DISEASES VIROLOGY PARASITOLOGY, 1986, 261 (01) :53-64

[9]

ISOGAI E, 1989, ZBL BAKT-INT J MED M, V271, P186

[10] In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis [J].

Isogai, E ;

Isogai, H ;

Kimura, K ;

Fujii, N ;

Takagi, S ;

Hirose, K ;

Hayashi, M .

INFECTION AND IMMUNITY, 1996, 64 (04) :1461-1466

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