Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

被引：20

作者：

Wallace, Michael D. ^{[1
]}

Waraich, Nidda F. ^{[2
]}

Debowski, Aleksandra W. ^{[1
,3
]}

Corral, Maxime G. ^{[1
,4
]}

Maxwell, Anthony ^{[2
]}

Mylne, Joshua S. ^{[1
,4
]}

Stubbs, Keith A. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Mol Sci, Crawley, WA 6009, Australia

[2] John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England

[3] Univ Western Australia, Sch Biomed Sci, Nedlands, WA 6009, Australia

[4] Univ Western Australia, ARC Ctr Excellence Plant Energy Biol, Nedlands, WA 6009, Australia

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 15期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

ARABIDOPSIS-THALIANA; EVOLUTION;

D O I：

10.1039/c7cc09518j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

引用

页码：1869 / 1872

页数：4

共 21 条

[1]

Bush N.G, 2015, ECOSAL PLUS, V6, DOI [10.1128/ecosalplus.ESP-0010-2014, DOI 10.1128/ECOSALPLUS.ESP-0010-2014]

[2] DNA gyrase is involved in chloroplast nucleoid partitioning [J].

Cho, HS ;

Lee, SS ;

Kim, KD ;

Hwang, I ;

Lim, JS ;

Park, YI ;

Pai, HS .

PLANT CELL, 2004, 16 (10) :2665-2682

[3] Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides [J].

Corral, Maxime G. ;

Leroux, Julie ;

Tresch, Stefan ;

Newton, Trevor ;

Stubbs, Keith A. ;

Mylne, Joshua S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (33) :9881-9885

[4] Herbicidal properties of antimalarial drugs [J].

Corral, Maxime G. ;

Leroux, Julie ;

Stubbs, Keith A. ;

Mylne, Joshua S. .

SCIENTIFIC REPORTS, 2017, 7

[5] Diglyceride prodrug strategy for enhancing the bioavailability of norfloxacin [J].

Dhaneshwar, Suneela ;

Tewari, Kunal ;

Joshi, Sonali ;

Godbole, Dhanashree ;

Ghosh, Pinaki .

CHEMISTRY AND PHYSICS OF LIPIDS, 2011, 164 (04) :307-313

[6] Glyphosate: a once-in-a-century herbicide [J].

Duke, Stephen O. ;

Powles, Stephen B. .

PEST MANAGEMENT SCIENCE, 2008, 64 (04) :319-325

[7] Why have no new herbicide modes of action appeared in recent years? [J].

Duke, Stephen O. .

PEST MANAGEMENT SCIENCE, 2012, 68 (04) :505-512

[8] Managing the evolution of herbicide resistance [J].

Evans, Jeffrey A. ;

Tranel, Patrick J. ;

Hager, Aaron G. ;

Schutte, Brian ;

Wu, Chenxi ;

Chatham, Laura A. ;

Davis, Adam S. .

PEST MANAGEMENT SCIENCE, 2016, 72 (01) :74-80

[9] DNA Gyrase Is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana [J].

Evans-Roberts, Katherine M. ;

Mitchenall, Lesley A. ;

Wall, Melisa K. ;

Leroux, Julie ;

Mylne, Joshua S. ;

Maxwell, Anthony .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (07) :3136-3144

[10] Combined molecular docking and QSAR study of fused heterocyclic herbicide inhibitors of D1 protein in photosystem II of plants [J].

Funar-Timofei, Simona ;

Borota, Ana ;

Crisan, Luminita .

MOLECULAR DIVERSITY, 2017, 21 (02) :437-454

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