Decline of Humoral and Cellular Immune Responses Against SARS-CoV-2 6 Months After Full BNT162b2 Vaccination in Hospital Healthcare Workers

被引：32

作者：

Bonnet, Benjamin ^{[1
,2
]}

Chabrolles, Helene ^{[3
,4
]}

Archimbaud, Christine ^{[3
,4
]}

Brebion, Amelie ^{[3
]}

Cosme, Justine ^{[1
]}

Dutheil, Frederic ^{[5
,6
]}

Lambert, Celine ^{[7
]}

Junda, Maud ^{[1
]}

Mirand, Audrey ^{[3
,4
]}

Ollier, Amandine ^{[8
]}

Pereira, Bruno ^{[7
]}

Regagnon, Christel ^{[3
]}

Vidal, Magali ^{[9
]}

Evrard, Bertrand ^{[1
,2
]}

Henquell, Cecile ^{[3
,4
]}

机构：

[1] CHU Clermont Ferrand, Clermont Ferrand Univ Hosp, Immunol Dept, Clermont Ferrand, France

[2] Clermont Auvergne Univ, UMR UNH, ECREIN, Clermont Ferrand, France

[3] CHU Clermont Ferrand, Clermont Ferrand Univ Hosp, 3IHP, Virol Dept, Clermont Ferrand, France

[4] Clermont Auvergne Univ, CNRS UMR, LMGE, Clermont Ferrand, France

[5] CHU Clermont Ferrand, Clermont Ferrand Univ Hosp, Prevent & Occupat Med, Clermont Ferrand, France

[6] Clermont Auvergne Univ, CNRS, LaPSCo Physiol & Psychosocial Stress, Clermont Ferrand, France

[7] CHU Clermont Ferrand, Clermont Ferrand Univ Hosp, Clin Res & Innovat Direct DRCI, Biostat Unit, Clermont Ferrand, France

[8] CHU Clermont Ferrand, Clermont Ferrand Univ Hosp, IHP 3, Clin Res & Innovat Direct, Clermont Ferrand, France

[9] CHU Clermont Ferrand, Clermont Ferrand Univ Hosp, IHP 3, Infect Dis Dept, Clermont Ferrand, France

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

B cell response; T cell response; interferon gamma (IFN gamma); COVID-19; mRNA vaccine;

D O I：

10.3389/fimmu.2022.842912

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical trials and real-world evidence on COVID-19 vaccines have shown their effectiveness against severe disease and death but the durability of protection remains unknown. We analysed the humoral and T-cell immune responses in 110 healthcare workers (HCWs) vaccinated according to the manufacturer's recommended schedule of dose 2 three weeks after dose 1 from a prospective on-going cohort in early 2021, 3 and 6 months after full vaccination with the BNT162b2 mRNA vaccine. Anti-RBD IgG titres were lower in HCWs over 60 years old 3 months after the second dose (p=0.03) and declined in all the subjects between 3 and 6 months with a median percentage change of -58.5%, irrespective of age and baseline comorbidities. Specific T-cell response measured by IGRA declined over time by at least 42% (median) in 91 HCWs and increased by 33% (median) in 17 others. Six HCWs had a negative T-cell response at 6 months. Ongoing follow-up should provide correlates of long-term protection according to the different immune response profiles observed.

引用

页数：11

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