Prognostic Significance of Tumor-Infiltrating Lymphocytes and the Tertiary Lymphoid Structures in HER2-Positive Breast Cancer Treated With Adjuvant Trastuzumab

被引：112
作者：
Lee, Hee Jin [1 ]
Kim, Joo Young [2 ]
Park, In Ah [1 ]
Song, In Hye [1 ]
Yu, Jong Han [3 ]
Ahn, Jin-Hee [4 ]
Gong, Gyungyub [1 ]
机构：
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 138736, South Korea
[2] Korea Univ, Coll Med, Anam Hosp, Dept Pathol, Seoul 136705, South Korea
[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Surg, Seoul 138736, South Korea
[4] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul 138736, South Korea
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2015年 / 144卷 / 02期
关键词：
Breast carcinoma; HER2; Trastuzumab; Lymphocytes; Tertiary lymphoid structure; MHC I; T-CELL INFILTRATION; RECEPTOR STATUS; CLASS-I; THERAPY; CHEMOTHERAPY; RECURRENCE; SYNERGIZES; PREDICTS; SURVIVAL; TISSUE;
D O I：
10.1309/AJCPIXUYDVZ0RZ3G
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Objectives: Tumor-infiltrating lymphocytes (TILs) have prognostic significance in breast cancer. The tertiary lymphoid structure (TLS) is related to the influx of TILs, and expression of major histocompatibility complex (MHC) I in tumor cells is necessary for the effective action of TILs. Methods: We retrospectively evaluated the relationship of TILs and TLS and the expression of MHC I in 447 HER2-positive breast cancers treated with chemotherapy and 1 year of trastuzumab. Results: TILs were more abundant in hormone receptor (HR)-/HER2+ tumors than in HR+/HER2+ tumors. HR-/HER2+ breast cancers with abundant TILs showed a higher histologic grade, the absence of lymphovascular invasion, the presence of peritumoral lymphocytic infiltration, moderate to abundant TLSs in adjacent tissue, and stronger HLA-ABC and HLA-A expression. Abundant TILs and the absence of lymphovascular invasion were found to be good, independent prognostic factors for disease-free survival in patients with HR-/HER2+ breast cancer. The level of TILs was not associated with the patients' prognosis in HR+ tumors. Conclusions: Abundant TILs are an independent prognostic factor in HR-/HER2+ breast cancers. Evaluation of TILs in HR-/HER2+ breast cancers may provide valuable information regarding the prognosis of patients treated using adjuvant chemotherapy and trastuzumab.
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页码：278 / 288
页数：11
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