Is PCOS an inflammatory process?

被引：232
作者：
Duleba, Antoni J. [1 ]
Dokras, Anuja [2 ]
机构：
[1] Univ Calif Davis, Dept Obstet & Gynecol, Sacramento, CA 95817 USA
[2] Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA
来源：
FERTILITY AND STERILITY | 2012年 / 97卷 / 01期
关键词：
PCOS; inflammation; CRP; interleukins; POLYCYSTIC-OVARY-SYNDROME; C-REACTIVE PROTEIN; GRADE CHRONIC INFLAMMATION; CORONARY HEART-DISEASE; NORMAL-WEIGHT WOMEN; INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; HELICOBACTER-PYLORI;
D O I：
10.1016/j.fertnstert.2011.11.023
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Pro-PCOS is associated with low-grade systemic inflammation as evidenced by elevation of multiple markers of inflammation such as C-reactive protein, interleukin-18, monocyte chemoattractant protein-1 and white blood cell count as well as endothelial dysfunction and increased oxidative stress. Con-Current studies examining the evidence for low grade inflammation in PCOS are small, heterogeneous for the diagnosis, confounded by degree of adiposity and do not consistently demonstrate a clinically relevant increase in the above mentioned biomarkers. (Fertil Steril (R) 2012;97: 7-12. (C) 2012 by American Society for Reproductive Medicine.)
引用
收藏
页码：7 / 12
页数：6
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