Dynamic regulation of PCNA ubiquitylation/deubiquitylation

被引：46

作者：

Fox, Jennifer T. ^{[1
]}

Lee, Kyoo-young ^{[1
]}

Myung, Kyungjae ^{[1
]}

机构：

[1] NHGRI, Genome Instabil Sect, Genet & Mol Biol Branch, NIH, Bethesda, MD 20892 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 18期

关键词：

Ubiquitylation; Deubiquitylation; PCNA; USP1; ELG1; CELL NUCLEAR ANTIGEN; GROSS CHROMOSOMAL REARRANGEMENTS; UBIQUITIN-PROTEIN LIGASE; DNA-POLYMERASE-ETA; POSTREPLICATION REPAIR; GENOMIC INSTABILITY; REPLICATION FORK; S-PHASE; MONOUBIQUITINATED PCNA; DEPENDENT DEGRADATION;

D O I：

10.1016/j.febslet.2011.05.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proliferating Cell Nuclear Antigen (PCNA) ubiquitylation plays a crucial role in maintaining genomic stability during DNA replication. DNA damage stalling the DNA replication fork induces PCNA ubiquitylation that activates DNA damage bypass to prevent the collapse of DNA replication forks that could potentially produce double-strand breaks and chromosomal rearrangements. PCNA ubiquitylation dictates the mode of bypass depending on the level of ubiquitylation; monoubiquitylation and polyubiquitylation activate error-prone translesion synthesis and error-free template switching, respectively. Due to the error-prone nature of DNA damage bypass, PCNA ubiquitylation needs to be tightly regulated. Here, we review the molecular mechanisms to remove ubiquitin from PCNA including the emerging role of USP1 and ELG1 in this fascinating process. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：2780 / 2785

页数：6