The can and can't dos of p53 RNA

被引：17
作者：
Candeias, Marco M. [1 ]
机构：
[1] Kyoto Univ, Lab Bioimaging & Cell Signaling, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068501, Japan
来源：
BIOCHIMIE | 2011年 / 93卷 / 11期
关键词：
p53; RNA; Bifunctional RNA; Mdm2; RIBOSOMAL-PROTEIN L26; WILD-TYPE P53; MESSENGER-RNA; DNA-DAMAGE; THYMIDYLATE SYNTHASE; TRANSLATION; MDM2; PHOSPHORYLATION; INITIATION; INDUCTION;
D O I：
10.1016/j.biochi.2011.06.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The p53 protein, like any other protein, cannot be made in the cell without RNA. And even once made, the p53 protein will be more rapidly degraded without the p53 RNA. Furthermore, the p53 RNA helps deciding which p53 isoform should be produced and under which cell conditions. Mutant p53 mRNA codes for an unstable and inactive protein. These matters are discussed in this article as well as the recent reports on p53 RNA mutations, interacting-proteins, 3' processing and 5'-3' loop. (C) 2011 Elsevier Masson SAS. All rights reserved.
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收藏
页码：1962 / 1965
页数：4
相关论文
共 45 条
[1]   Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage [J].
Batchelor, Eric ;
Mock, Caroline S. ;
Bhan, Irun ;
Loewer, Alexander ;
Lahav, Galit .
MOLECULAR CELL, 2008, 30 (03) :277-289
[2]   p53 isoforms can regulate p53 transcriptional activity [J].
Bourdon, JC ;
Fernandes, K ;
Murray-Zmijewski, F ;
Liu, G ;
Diot, A ;
Xirodimas, DP ;
Saville, MK ;
Lane, DP .
GENES & DEVELOPMENT, 2005, 19 (18) :2122-2137
[3]   Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation [J].
Candeias, M. M. ;
Powell, D. J. ;
Roubalova, E. ;
Apcher, S. ;
Bourougaa, K. ;
Vojtesek, B. ;
Bruzzoni-Giovanelli, H. ;
Fahraeus, R. .
ONCOGENE, 2006, 25 (52) :6936-6947
[4]   p53 mrNA controls p53 activity by managing Mdm2 functions [J].
Candeias, Marco M. ;
Malbert-Colas, Laurence ;
Powell, Darren J. ;
Daskalogianni, Chrysoula ;
Maslon, Magda M. ;
Naski, Nadia ;
Bourougaa, Karima ;
Calvo, Fabien ;
Fahraeus, Robin .
NATURE CELL BIOLOGY, 2008, 10 (09) :1098-1105
[5]  
CHEN J, GENES DEV, V24, P2146
[6]   Interaction of heterogeneous nuclear ribonucleoprotein C1/C2 with a novel cis-regulatory element within p53 mRNA as a response to cytostatic drug treatment [J].
Christian, Kyle J. ;
Lang, Matti A. ;
Raffalli-Mathieu, Francoise .
MOLECULAR PHARMACOLOGY, 2008, 73 (05) :1558-1567
[7]  
Chu E, 1999, MOL CELL BIOL, V19, P1582
[8]   ΔN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53 [J].
Courtois, S ;
Verhaegh, G ;
North, S ;
Luciani, MG ;
Lassus, P ;
Hibner, U ;
Oren, M ;
Hainaut, P .
ONCOGENE, 2002, 21 (44) :6722-6728
[9]   ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation [J].
Craig, Ashley L. ;
Holcakova, Jitka ;
Finlan, Lee E. ;
Nekulova, Marta ;
Hrstka, Roman ;
Gueven, Nuri ;
DiRenzo, James ;
Smith, Graeme ;
Hupp, Ted R. ;
Vojtesek, Borivoj .
MOLECULAR CANCER, 2010, 9
[10]  
Decorsiere A, GENES DEV, V25, P220
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