Eosinophilic Esophagitis

被引：10

作者：

Katzka, David A. ^{[1
]}

机构：

[1] Mayo Clin, Rochester, MN 55905 USA

来源：

ANNALS OF INTERNAL MEDICINE | 2020年 / 172卷 / 09期

关键词：

6-FOOD ELIMINATION DIET; PEDIATRIC-PATIENTS; PREVALENCE; POPULATION; CHILDREN; METAANALYSIS; EFFICACY; DISEASE; ADULTS; MANAGEMENT;

D O I：

10.7326/AITC202005050

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eosinophilic esophagitis (EoE) is a relatively new disease that has reached an incidence similar to that of Crohn disease and ulcerative colitis. With this increased presence, greater recognition is essential. This applies both to children with nonspecific but potentially debilitating symptoms and to adults who have spent years behaviorally compensating for narrow esophageal strictures. The pathogenesis of EoE is rapidly being unraveled and is based on initiation of a type II allergic response to specific food antigens, leading to dense esophageal eosinophilia, chronic inflammation, and esophageal fibrosis. With greater familiarity and understanding of EoE, treatments are evolving, including identification and avoidance of food antigens; broad applications of topical steroids; and, eventually, pathway-specific biologic therapy.

引用

页码：ITC65 / ITC78

页数：14

共 77 条

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