Squamous Lesions of the Ovary

The ovary shows an innate potential for markedly variable histogenesis, including squamous differentiation. Although not uncommon, squamous differentiation in ovarian lesions can be present in several diagnostic contexts, both benign and malignant. We present a review of the literature pertaining to squamous lesions of the ovary. In particular, we summarize the relevant clinical features, workup, gross findings and histopathologic features, differential diagnosis, treatment, and prognostic features of both the common and rare squamous entities found in the ovary. (Arch Pathol Lab Med. 2011; 135:1611-1614; doi:10.5858/arpa.2010-0640-RS)