Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes

被引：95

作者：

Donohoe, Timothy J. ^{[1
]}

Kabeshov, Mikhail A. ^{[1
]}

Rathi, Akshat H. ^{[1
]}

Smith, Ian E. D. ^{[2
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

[2] GlaxoSmithKline Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

ONE-POT SYNTHESIS; FACILE SYNTHESIS; ALKYL-HALIDES; OXIDATION; DERIVATIVES; OLEFINS; IODINE; 2-AMINOTHIAZOLES; DEHYDROGENATION; INHIBITORS;

D O I：

10.1039/c1ob06587d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and regioselectivity.

引用

页码：1093 / 1101

页数：9

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