IGF-1 MINIMIZES THE HARMFUL EFFECTS OF DISUSE ON RAT SOLEUS MUSCLE

被引：1
作者：
da Silva, Carlos Alberto [1 ]
Petermann, Carlos [1 ]
Cancelliero, Karina Maria [1 ]
Quagliotti Durigan, Joao Luiz [1 ]
Ozores Polacow, Maria Luiza [1 ]
机构：
[1] Univ Metodista Piracicaba, Fac Ciencias Saude, PPG FISIOTERAPIA, BR-13400911 Sao Paulo, Brazil
来源：
ACTA ORTOPEDICA BRASILEIRA | 2011年 / 19卷 / 03期
关键词：
Insulin-like growth factor I; Immobilization; Glycogen; Skeletal; muscle; GROWTH-FACTOR-I; INTRAMUSCULAR CONNECTIVE-TISSUE; SKELETAL-MUSCLE; INSULIN; METABOLISM; PROTEIN;
D O I：
10.1590/S1413-78522011000300004
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Objective: To evaluate the effect of IGF-1 treatment on the morphological and metabolic profile of the soleus muscle submitted to ankle joint immobilization. Methods: Wistar rats were divided into 3 groups (n = 6): control (C), immobilized (I) and immobilized treated with IGF (I + IGF; 40mg/kg) for 7 days. Results: Immobilization led to a reduction in the weight (34%), glycogen content (31.6%) and area of muscle fibers (44%), and increased the density of connective tissue (216%). Also, the IGF-1 increased the glycogen by 234.6% compared to I, minimized the area of muscle fibers by 33.7% and increased the connective tissue by 76% compared to C (p <0, 05). Conclusions: Treatment with IGF has an anti-catabolic action, which can promote faster recovery in the post-immobilization phase. Level of Evidence: Level II, prospective comparative study.
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页码：137 / 140
页数：4
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