When DNA Polymerases Multitask: Functions Beyond Nucleotidyl Transfer

被引：9

作者：

Carvajal-Maldonado, Denisse ^{[1
]}

Drogalis Beckham, Lea ^{[2
]}

Wood, Richard D. ^{[1
]}

Doublie, Sylvie ^{[2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Epigenet & Mol Carcinogenesis, Houston, TX 77030 USA

[2] Univ Vermont, Dept Microbiol & Mol Genet, Burlington, VT 05405 USA

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2022年 / 8卷

基金：

美国国家卫生研究院;

关键词：

DNA polymerases; nucleotidyl transfer; DNA repair; nuclease activity; lyase activity; proofreading; BASE EXCISION-REPAIR; DEOXYRIBOSE PHOSPHATE LYASE; ACTIVE-SITE; EXONUCLEASE ACTIVITY; CRYSTAL-STRUCTURE; BETA; RNA; CLEAVAGE; BINDING; DOMAIN;

D O I：

10.3389/fmolb.2021.815845

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerases catalyze nucleotidyl transfer, the central reaction in synthesis of DNA polynucleotide chains. They function not only in DNA replication, but also in diverse aspects of DNA repair and recombination. Some DNA polymerases can perform translesion DNA synthesis, facilitating damage tolerance and leading to mutagenesis. In addition to these functions, many DNA polymerases conduct biochemically distinct reactions. This review presents examples of DNA polymerases that carry out nuclease (3MODIFIER LETTER PRIME-5 ' exonuclease, 5 ' nuclease, or end-trimming nuclease) or lyase (5 ' dRP lyase) extracurricular activities. The discussion underscores how DNA polymerases have a remarkable ability to manipulate DNA strands, sometimes involving relatively large intramolecular movement.

引用

页数：10