Occurrence of bufotenin in the Osteocephalus genus (Anura: Hylidae)

被引：10

作者：

Costa, TOG

Morales, RAV

Brito, JP

Gordo, M

Pinto, AC

Bloch, C

机构：

[1] Embrapa Recursos Genet & Biotecnol, Lab Espectrometria Massa, Brasilia, DF, Brazil

[2] Univ Fed Amazonas, Dept Quim Organ, Lab Prod Nat, BR-69077000 Manaus, Amazonas, Brazil

[3] Univ Fed Rio de Janeiro, Inst Quim, Lab Sintese Organ & Prod Nat, BR-21941590 Rio De Janeiro, Brazil

[4] Univ Fed Amazonas, Inst Ciencias Biol, Dept Biol, BR-69077000 Manaus, Amazonas, Brazil

来源：

TOXICON | 2005年 / 46卷 / 04期

关键词：

bufotenin; Osteocephalus; tryptamine alkaloid; ESI/MS/MS; NMR;

D O I：

10.1016/j.toxicon.2005.02.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bufotenin (5-hydroxy-N,N-dimetyltryptamine) is a tryptamine alkaloid widely spread among anuran families as a component of their chemical defense system, acting as a potent hallucinogenic factor, showing similar activity to LSD upon interaction with the 5HT(2) human receptor. This work demonstrates the presence of bufotenin in the skin secretion of three arboreal amphibian species of the Osteocephalus genus (Osteocephalus taurinus, Osteocephalus oophagus and Osteocephalus langsdorffii) from the Amazon and the Atlantic rain forests using RP-HPLC, ESI-MS/MS; UV, IR and multidimensional NMR techniques. To our knowledge, this is the first description of bufotenin in the Osteocephalus genus, so far. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：371 / 375

页数：5

共 16 条

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