Exploration of Rapid Evaporative-Ionization Mass Spectrometry as a Shotgun Approach for the Comprehensive Characterization of Kigelia Africana (Lam) Benth. Fruit

被引:18
作者
Arena, Katia [1 ,2 ]
Rigano, Francesca [2 ]
Mangraviti, Domenica [2 ]
Cacciola, Francesco [3 ]
Occhiuto, Francesco [2 ]
Dugo, Laura [4 ]
Dugo, Paola [2 ,5 ]
Mondello, Luigi [2 ,4 ,5 ,6 ]
机构
[1] Univ Messina, Fdn A Imbesi, I-98168 Messina, Italy
[2] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, I-98168 Messina, Italy
[3] Univ Messina, Dept Biomed Dent Morphol & Funct Imaging Sci, I-98168 Messina, Italy
[4] Univ Campus Biomed Rome, Dept Sci & Technol Human & Environm, I-00128 Rome, Italy
[5] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Chromaleont Srl, I-98168 Messina, Italy
[6] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, BeSep Srl, I-98168 Messina, Italy
来源
MOLECULES | 2020年 / 25卷 / 04期
关键词
REIMS; direct infusion in mass spectrometry; mass accuracy; tandem MS; Kigelia africana fruit; bioactive molecules; lipids; phenols; IDENTIFICATION; TISSUE; PRODUCTS; PLATFORM;
D O I
10.3390/molecules25040962
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rapid evaporative-ionization mass spectrometry (REIMS) coupled with an electroknife as a sampling device was recently employed in many application fields to obtain a rapid characterization of different samples without any need for extraction or cleanup procedures. In the present research, REIMS was used to obtain a metabolic profiling of the Kigelia africana fruit, thus extending the applicability of such a technique to the investigation of phytochemical constituents. In particular, the advantages of REIMS linked to a typical electrosurgical handpiece were applied for a comprehensive screening of this botanical species, by exploiting the mass accuracy and tandem MS capabilities of a quadrupole-time of flight analyzer. Then, 78 biomolecules were positively identified, including phenols, fatty acids and phospholipids. In the last decade, Kigelia africana (Lam.) Benth. fruit has attracted special interest for its drug-like properties, e.g., its use for infertility treatments and as anti-tumor agent, as well as against fungal and bacterial infections, diabetes, and inflammatory processes. Many of these properties are currently correlated to the presence of phenolic compounds, also detected in the present study, while the native lipid composition is here reported for the first time and could open new directions in the evaluation of therapeutic activity.
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页数:19
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