Dialiumoside, an Olean-18-ene Triterpenoid from Dialium excelsum

被引：20

作者：

Awantu, Angelbert F. ^{[2
,3
]}

Lenta, Bruno N. ^{[1
]}

Bogner, Tobias ^{[3
]}

Fongang, Yanick F. ^{[2
]}

Ngouela, Silvere ^{[2
]}

Wansi, Jean D. ^{[3
]}

Tsamo, Etienne ^{[2
]}

Sewald, Norbert ^{[3
]}

机构：

[1] Univ Yaounde 1, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon

[2] Univ Yaounde 1, Fac Sci, TWAS Res Unit, Dept Organ Chem, Yaounde, Cameroon

[3] Univ Bielefeld, Dept Chem Organ & Bioorgan Chem, D-33501 Bielefeld, Germany

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2011年 / 66卷 / 06期

关键词：

Dialium excelsum; Dialiumoside; Triterpenoids; Cytotoxicity; KB-3-1 and KB-V1 Cells; C-13; NMR-SPECTRA; PENTACYCLIC TRITERPENOIDS; GUINEENSE; CONSTITUENTS;

D O I：

10.5560/ZNB.2011.66b0624

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Phytochemical investigation of the stem bark and fruits of Dialium excelsum led to the isolation of a new triterpenoid, named dialiumoside (1), together with twelve known compounds (2-13). The structure of the new compound as well as those of the known compounds were established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1-13 were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and the related multi drug-resistant P-gp-expressing KB-V1 cells. Compounds 1 and 13 showed weak biological activity in cytotoxicity assays while other compounds were inactive.

引用

页码：624 / 628

页数：5

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