Regioselective ring opening of enantiomerically enriched epoxides via catalysis with chiral (salen)Cr(III) complexes

被引：0

作者：

Brandes, BD ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

SYNLETT | 2001年

关键词：

regioselectivity; ring opening; (salen)Cr(III) complexes; epoxides;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral (salen)chromium(III)N-3 complexes are demonstrated to be catalysts for the regioselective ring opening a variety of enantiomerically enriched epoxides. Selective nucleophilic attack at either epoxide carbon atom can be achieved by selection of the appropriate enantiomer of catalyst. A highly selective synthesis of norpseudoephedrine is described using this strategy.

引用

页码：1013 / 1015

页数：3

共 17 条

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