Heterocyclic ketones as inhibitors of histone deacetylase

被引：41
|
作者：
Vasudevan, A
Li, ZQ
Frey, RR
Wada, CK
Steinman, D
Heyman, HR
Guo, Y
Curtin, ML
Guo, J
Li, JL
Pease, L
Glaser, KB
Marcotte, PA
Bouska, JJ
Davidsen, SK
Michaelides, MR
机构：
[1] Abbott Labs, Med Chem Technol, Abbott Pk, IL 60064 USA
[2] Abbott Labs, Canc Res, Abbott Pk, IL 60064 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 22期
关键词：
D O I：
10.1016/j.bmcl.2003.09.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition. (C) 2003 Published by Elsevier Ltd.
引用
收藏
页码：3909 / 3913
页数：5
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