Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

被引：106

作者：

Zhang, Weijie ^{[1
,2
]}

Kwok, Ryan T. K. ^{[2
,3
]}

Chen, Yilong ^{[2
,3
]}

Chen, Sijie ^{[2
,3
]}

Zhao, Engui ^{[2
,3
]}

Yu, Chris Y. Y. ^{[2
,3
]}

Lam, Jacky W. Y. ^{[2
,3
]}

Zheng, Qichang ^{[1
]}

Tang, Ben Zhong ^{[2
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Hepatobiliary Surg, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Div Life Sci,Inst Mol Funct Mat, Dept Chem,Inst Adv Study,Div Biomed Engn, Kowloon, Hong Kong, Peoples R China

[3] HKUST Shenzhen Res Inst, Shenzhen 518057, Peoples R China

[4] S China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangdong Innovat Res Team, SCUT HKUST Joint Res Lab, Guangzhou 510640, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 43期

关键词：

AGGREGATION-INDUCED-EMISSION; LIGHT-UP PROBE; QUANTUM DOTS; AUTOPHAGY; DEFENSE;

D O I：

10.1039/c5cc02486b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An isothiocyanate-functionalized tetraphenylethene is synthesized and used as a fluorescent bioprobe for mitochondrion imaging with high specificity and photostability. The covalent conjugation of the bioprobe to mitochondrial proteins endows it with high resistance to microenvironmental changes, enabling it for real-time monitoring of mitophagy.

引用

页码：9022 / 9025

页数：4