Sulfated liposaccharides inspired by telomerase inhibitor axinelloside A

被引：8
作者：
Guang, Jie [1 ]
Rumlow, Zachary A. [1 ]
Wiles, Lauren M. [1 ]
O'Neill, Sloane [1 ]
Walczak, Maciej A. [1 ]
机构：
[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 52期
关键词：
Liposaccharides; Sulfated saccharides; Telomerase; Sulfate esters; SULFURYL IMIDAZOLIUM SALTS; TARGETING TELOMERASE; G-QUADRUPLEX; CANCER; CELLS; OLIGONUCLEOTIDE; EFFICIENT; MULTIPLE; THERAPEUTICS; DEPROTECTION;
D O I：
10.1016/j.tetlet.2017.11.038
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Sulfated liposaccharides are known inhibitors of telomerase and here we describe the synthesis of a series of sulfated liposaccharides inspired by the natural product axinelloside A, reported to act as an inhibitor of human telomerase. We established a robust and scalable synthetic route to galactosyl liposaccharides capitalizing on a series of regioselective acylation reactions with 2-decenoic acid and imidazolium sulfate esters. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4867 / 4871
页数：5
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