Non-coding RNAs in Ischemic Stroke: Roles in the Neuroinflammation and Cell Death

被引：20

作者：

Lu, Meng ^{[1
,2
]}

Dong, Xingang ^{[3
]}

Zhang, Zhenqiang ^{[1
]}

Li, Weifeng ^{[4
]}

Khoshnam, Seyed Esmaeil ^{[5
]}

机构：

[1] Henan Univ Chinese Med, Acad Tradit Chinese Med, Zhengzhou 450046, Peoples R China

[2] Hebei Univ Chinese Med, Coll Integrat Chinese & Western Med, Shijiazhuang 050200, Hebei, Peoples R China

[3] Henan Univ Chinese Med, Frist Clin Med Coll, Zhengzhou 450008, Peoples R China

[4] Henan Univ Chinese Med, Clin Med Coll 3, Zhengzhou 450008, Peoples R China

[5] Ahvaz Jundishapur Univ Med Sci, Physiol Res Ctr, Ahvaz, Iran

来源：

NEUROTOXICITY RESEARCH | 2020年 / 38卷 / 03期

关键词：

Non-coding RNAs; Ischemic stroke; Cell death; Neuroinflammation; FOCAL CEREBRAL-ISCHEMIA; TRAUMATIC BRAIN-INJURY; COMMON CAROTID OCCLUSION; CIRCULAR RNAS; ISCHEMIA/REPERFUSION INJURY; MOUSE-BRAIN; EMERGING ROLES; EXPRESSION PROFILES; REPERFUSION INJURY; ENDOTHELIAL-CELLS;

D O I：

10.1007/s12640-020-00236-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ischemic stroke is one of the leading causes of death and long-term disability worldwide. As an important class of pervasive genes involved in many pathophysiological processes of ischemic stroke, non-coding RNAs (ncRNAs) have received attention in the past decades. ncRNAs are a class of functional RNAs that regulate gene expression in a post-transcriptional manner, and including microRNAs, long non-coding RNAs, and circular RNAs. Several studies have deciphered that ncRNAs have a key role in the ischemic stroke-induced neuroinflammation and cell death via different molecules and pathways. Thus, ncRNAs show great promise as novel molecular targets in ischemic stroke. In this article, we provide an updated review of the current state of our knowledge about the roles of different types of ncRNAs in neuroinflammation and cell death following ischemic stroke, which may facilitate the translation of ncRNAs research into clinical practice to improve the clinical outcome of stroke therapy.

引用

页码：564 / 578

页数：15