LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma

被引：16

作者：

Huang, Qiang ^{[1
]}

Yang, Jiao ^{[1
]}

He, Xin ^{[1
]}

Shi, Shuyan ^{[1
]}

Xing, Shuxing ^{[1
]}

机构：

[1] Chengdu Fifth Peoples Hosp, Dept Orthopaed, Chengdu 611130, Sichuan, Peoples R China

来源：

BIOSCIENCE REPORTS | 2018年 / 38卷

关键词：

EXPRESSION;

D O I：

10.1042/BSR20181498

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNA (LncRNA) brain-derived neurotrophic factor antisense (BDNF-AS) has been found to be down-regulated and function in a tumor suppressive role in human cancers. However, the expression status and function of BDNF-AS is still unknown in osteosarcoma (OS). In our study, BDNF-AS expression was found to be decreased in OS tissues and cells. Moreover, BDNF-AS low expression was correlated with advanced Enneking stage, large tumor size and poor prognosis in OS patients. The multivariate analysis suggested low expression of BDNF-AS was an independent unfavorable prognostic factor for overall survival in OS patients. The in vitro studies indicated that BDNF-AS overexpression inhibits OS cell proliferation and promotes cell apoptosis through regulating cleaved caspase-3. In conclusion, BDNF-AS serves as a tumor suppressive lncRNA in OS.

引用

页数：7

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