Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies

被引：32

作者：

Fourcade, Camille ^{[1
]}

Mansuy, Jean-Michel ^{[1
]}

Dutertre, Marine ^{[1
]}

Delpech, Marie ^{[2
]}

Marchou, Bruno ^{[1
]}

Delobel, Pierre ^{[1
,3
]}

Izopet, Jacques ^{[1
,3
]}

Martin-Blondel, Guillaume ^{[1
,3
]}

机构：

[1] Toulouse Univ Hosp, Toulouse, France

[2] St Gaudens Hosp, St Gaudens, France

[3] INSERM, UMR1043, Toulouse, France

来源：

JOURNAL OF CLINICAL VIROLOGY | 2016年 / 82卷

关键词：

Zika virus infection; Kinetics; Plasma; Urine; RNA; Antibodies; INFECTION; TRANSMISSION; EPIDEMIC; BRAZIL;

D O I：

10.1016/j.jcv.2016.06.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

While the rapid spread of Zika virus (ZIKV) in South America has been declared a public health emergency few data are available on the kinetics of the virus load and the specific antibodies in individual patients. This report describes the kinetics of ZIKV decay in the body compartments and the kinetics of anti ZIKV IgG and IgM of two people returning from Martinique, French West Indies. ZIKV remained detectable in the plasma for roughly 2 weeks indicating that mosquito control measures should be prolonged accordingly. Remarkably, their urine samples consistently tested positive for even longer. The antibodies responses were different between the two patients but for both the rapid onset of IgM allowed a diagnosis from the end of the first week. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1 / 4

页数：4

共 18 条

[1]

[Anonymous], EURO SURVEILL

[2]

Brasil P., 2016, N ENGL J MED

[3] Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil [J].

Campos, Renata de M. ;

Cirne-Santos, Claudio ;

Meira, Guilherme L. S. ;

Santos, Luana L. R. ;

de Meneses, Marcelo D. ;

Friedrich, Johannes ;

Jansen, Stephanie ;

Ribeiro, Mario S. ;

da Cruz, Igor C. ;

Schmidt-Chanasit, Jonas ;

Ferreira, Davis F. .

JOURNAL OF CLINICAL VIROLOGY, 2016, 77 :69-70

[4] Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study [J].

Cao-Lormeau, Van-Mai ;

Blake, Alexandre ;

Mons, Sandrine ;

Lastere, Stephane ;

Roche, Claudine ;

Vanhomwegen, Jessica ;

Dub, Timothee ;

Baudouin, Laure ;

Teissier, Anita ;

Larre, Philippe ;

Vial, Anne-Laure ;

Decam, Christophe ;

Choumet, Valerie ;

Halstead, Susan K. ;

Willison, Hugh J. ;

Musset, Lucile ;

Manuguerra, Jean-Claude ;

Despres, Philippe ;

Fournier, Emmanuel ;

Mallet, Henri-Pierre ;

Musso, Didier ;

Fontanet, Arnaud ;

Neil, Jean ;

Ghawche, Frederic .

LANCET, 2016, 387 (10027) :1531-1539

[5] Emerging arboviruses in the Pacific [J].

Cao-Lormeau, Van-Mai ;

Musso, Didier .

LANCET, 2014, 384 (9954) :1571-1572

[6]

European Centre for Disease Prevention and Control. Rapid Risk Assessment, 2016, ZIK VIR DIS EP POT A

[7] Detection of Zika Virus in Urine [J].

Gourinat, Ann-Claire ;

O'Connor, Olivia ;

Calvez, Elodie ;

Goarant, Cyrille ;

Dupont-Rouzeyrol, Myrielle .

EMERGING INFECTIOUS DISEASES, 2015, 21 (01) :84-86

[8] Zika Virus Infection, Cambodia, 2010 [J].

Heang, Vireak ;

Yasuda, Chadwick Y. ;

Sovann, Ly ;

Haddow, Andrew D. ;

da Rosa, Amelia P. Travassos ;

Tesh, Robert B. ;

Kasper, Matthew R. .

EMERGING INFECTIOUS DISEASES, 2012, 18 (02) :349-351

[9]

Huzly D., 2016, EURO SURVEILL, V21

[10] Genetic and serologic properties of zika virus associated with an epidemic, Yap State, Micronesia, 2007 [J].

Lanciotti, Robert S. ;

Kosoy, Olga L. ;

Laven, Janeen J. ;

Velez, Jason O. ;

Lambert, Amy J. ;

Johnson, Alison J. ;

Stanfield, Stephanie M. ;

Duffy, Mark R. .

EMERGING INFECTIOUS DISEASES, 2008, 14 (08) :1232-1239

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