共 20 条
E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming
被引:246
作者:

Redmer, Torben
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h-index: 0
机构:
Max Delbrueck Ctr, D-13125 Berlin, Germany
Free Univ Berlin, Dept Biol Chem & Pharm, D-14195 Berlin, Germany Max Delbrueck Ctr, D-13125 Berlin, Germany

Diecke, Sebastian
论文数: 0 引用数: 0
h-index: 0
机构:
Max Delbrueck Ctr, D-13125 Berlin, Germany
Free Univ Berlin, Dept Biol Chem & Pharm, D-14195 Berlin, Germany Max Delbrueck Ctr, D-13125 Berlin, Germany

Grigoryan, Tamara
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h-index: 0
机构:
Max Delbrueck Ctr, D-13125 Berlin, Germany
Humboldt Univ, Fac Math & Nat Sci 1, D-10099 Berlin, Germany Max Delbrueck Ctr, D-13125 Berlin, Germany

Quiroga-Negreira, Angel
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h-index: 0
机构:
Max Delbrueck Ctr, D-13125 Berlin, Germany
Humboldt Univ, Fac Math & Nat Sci 1, D-10099 Berlin, Germany Max Delbrueck Ctr, D-13125 Berlin, Germany

Birchmeier, Walter
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h-index: 0
机构:
Max Delbrueck Ctr, D-13125 Berlin, Germany Max Delbrueck Ctr, D-13125 Berlin, Germany

Besser, Daniel
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h-index: 0
机构:
Max Delbrueck Ctr, D-13125 Berlin, Germany Max Delbrueck Ctr, D-13125 Berlin, Germany
机构:
[1] Max Delbrueck Ctr, D-13125 Berlin, Germany
[2] Free Univ Berlin, Dept Biol Chem & Pharm, D-14195 Berlin, Germany
[3] Humboldt Univ, Fac Math & Nat Sci 1, D-10099 Berlin, Germany
关键词:
pluripotency;
somatic cell reprogramming;
E-cadherin;
OCT4;
SELF-RENEWAL;
CONTACT;
D O I:
10.1038/embor.2011.88
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse fibroblasts by OCT4, SOX2, KLF4 and c-MYC, fully reprogrammed cells were exclusively observed in the E-cadherinpositive cell population and could not be obtained in the absence of E-cadherin. Moreover, reprogrammed cells could be established by viral E-cadherin in the absence of exogenous OCT4. Thus, reprogramming requires spatial cues that cross-talk with essential transcription factors. The cell-adhesion molecule E-cadherin has important functions in pluripotency and reprogramming.
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收藏
页码:720 / 726
页数:7
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论文数: 引用数:
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Doble, Bradley W.
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McMaster Univ, Stem Cell & Canc Res Inst, Hamilton, ON L8N 3Z5, Canada
McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Stem Cell & Canc Res Inst, Hamilton, ON L8N 3Z5, Canada