A virus-mimetic nanogel vehicle

被引：173

作者：

Lee, Eun Seong ^{[2
]}

Kim, Dongin ^{[1
]}

Youn, Yu Seok ^{[1
]}

Oh, Kyung Taek ^{[1
]}

Bae, You Han ^{[1
]}

机构：

[1] Univ Utah, Dept Pharmaceut & Phamaceut Chem, Salt Lake City, UT 84108 USA

[2] Catholic Univ Korea, Div Biotechnol, Bucheon Si 420743, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 13期

关键词：

antitumor agents; drug delivery; gels; nanotechnology; viruses;

D O I：

10.1002/anie.200704121

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Delivering the goods: A pH-sensitive nanogel consists of a hydrophobic copolymer core and two layers of hydrophilic shell (see picture). The core is loaded with a model anticancer drug, doxorubicin (DOX). The nanogel infects tumor cells in a receptor-dependent manner, kills the cells, and migrates to neighboring cells like a virus. BSA = bovine serum albumin, F = folate, PEG = polyethylene glycol. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2418 / 2421

页数：4

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