The treatment of oropharyngeal candidiasis in HIV-infected patients with oral amphotericin B suspension

被引:7
作者
Hood, S
Evans, J
Bond, J
Wilkins, B
Denning, D
机构
[1] N Manchester Gen Hosp, Monsall Unit, Dept Infect Dis & Trop Med, Manchester M8 6RL, Lancs, England
[2] Univ Manchester, Hope Hosp, Dept Med, Sect Infect Dis, Salford M6 8HD, Lancs, England
关键词
D O I
10.1089/apc.1998.12.625
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Oropharyngeal candidiasis (OPC) is the most frequent opportunistic infection associated with HIV infection. Therapies such as topical clotrimazole and nystatin, as well as oral azoles, which had previously been effective prior to the advent of HIV, are increasingly only partially effective in OPC in HIV infection. The effectiveness of oral amphotericin B suspension for OPC is described in 17 HIV-infected patients whose response to other therapies had been unsatisfactory. Three patients yielded isolates of Candida albicans with a minimum inhibitory concentration (MIC) to fluconazole of greater than or equal to 16 mu g/mL. Eleven patients received amphotericin B suspension monotherapy. Of the 17 patients, the symptoms of six resolved entirely, seven patients partially responded, and four failed therapy. These data suggest that amphotericin B suspension may be a useful additional therapy for OPC in HIV-infected patients.
引用
收藏
页码:625 / 627
页数:3
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