Human neurodegenerative disease modeling using Drosophila

被引：124

作者：

Bonini, NM

Fortini, ME

机构：

[1] Univ Penn, Howard Hughes Med Inst, Dept Biol, Philadelphia, PA 19104 USA

[2] NCI, Div Basic Sci, Ft Detrick, MD 21702 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2003年 / 26卷

关键词：

polyglutamine; tau; presenilin; Alzheimer's disease; Parkinson's disease;

D O I：

10.1146/annurev.neuro.26.041002.131425

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A number of approaches have been taken to recreate and to study the role of genes associated with human neurodegenerative diseases in the model organism Drosophila. These studies encompass the polyglutamine diseases, Parkinson's disease, Alzheimer's disease, and tau-associated pathologies. The findings highlight Drosophila as an important model system in which to study the fundamental pathways influenced by these genes and have led to new insights into aspects of pathogenesis and modifier mechanisms.

引用

收藏

页码：627 / 656

页数：34

相关论文

共 179 条

[31] Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein [J].

De Strooper, B ;

Saftig, P ;

Craessaerts, K ;

Vanderstichele, H ;

Guhde, G ;

Annaert, W ;

Von Figura, K ;

Van Leuven, F .

NATURE, 1998, 391 (6665) :387-390

[32] Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells [J].

Deng, GM ;

Pike, CJ ;

Cotman, CW .

FEBS LETTERS, 1996, 397 (01) :50-54

[33] Protein topology of presenilin 1 [J].

Doan, A ;

Thinakaran, G ;

Borchelt, DR ;

Slunt, HH ;

Ratovitsky, T ;

Podlisny, M ;

Selkoe, DJ ;

Seeger, M ;

Gandy, SE ;

Price, DL ;

Sisodia, SS .

NEURON, 1996, 17 (05) :1023-1030

[34] Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease [J].

El-Agnaf, OMA ;

Jakes, R ;

Curran, MD ;

Wallace, A .

FEBS LETTERS, 1998, 440 (1-2) :67-70

[35] Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality [J].

Elefant, F ;

Palter, KB .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (07) :2101-2117

[36] Activity-dependent isolation of the presenilin-γ-secretase complex reveals nicastrin and a γ substrate [J].

Esler, WP ;

Kimberly, WT ;

Ostaszewski, BL ;

Ye, WJ ;

Diehl, TS ;

Selkoe, DJ ;

Wolfe, MS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) :2720-2725

[37] Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1 [J].

Esler, WP ;

Kimberly, WT ;

Ostaszewski, BL ;

Diehl, TS ;

Moore, CL ;

Tsai, JY ;

Rahmati, T ;

Xia, WM ;

Selkoe, DJ ;

Wolfe, MS .

NATURE CELL BIOLOGY, 2000, 2 (07) :428-434

[38] Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron [J].

Faber, PW ;

Alter, JR ;

MacDonald, ME ;

Hart, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) :179-184

[39] A Drosophila model of Parkinson's disease [J].

Feany, MB ;

Bender, WW .

NATURE, 2000, 404 (6776) :394-398

[40] Identification of genes that modify ataxin-1-induced neurodegeneration [J].

Fernandez-Funez, P ;

Nino-Rosales, ML ;

de Gouyon, B ;

She, WC ;

Luchak, JM ;

Martinez, P ;

Turiegano, E ;

Benito, J ;

Capovilla, M ;

Skinner, PJ ;

McCall, A ;

Canal, I ;

Orr, HT ;

Zoghbi, HY ;

Botas, J .

NATURE, 2000, 408 (6808) :101-106

← 1 2 3 4 5 6 7 8 9 10 →