Effect of atmospheric ammonia on mortality rate of rats with barbiturate intoxication

被引：2

作者：

Rejniuk, V. L. ^{[1
]}

Schafer, T. V. ^{[1
]}

Ovsep'yan, R. V. ^{[1
]}

Ivnitsky, J. J. ^{[1
]}

机构：

[1] Mil Med Acad, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 143卷 / 06期

关键词：

sodium thiopental; atmospheric ammonia; blood ammonia; ammonium acetate; mortality;

D O I：

10.1007/s10517-007-0216-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ammonia inhalation (0.84-1.07 mg/liter, 3 h) was accompanied by a 65% increase in ammonia concentration in mixed blood of intact rats. This treatment did not cause death of intact animals, but potentiated the lethal effect of sodium thiopental and inhibited external respiration and O-2 consumption in animals. The resistance of rats to the lethal effect of barbiturate tended to decrease under conditions of experimental hyperammonemia induced by intraperitoneal injection of ammonium acetate in a nonlethal dose (6 mmol/kg). Our results indicate that potentiation of the toxic effect of barbiturates by atmospheric ammonia is related to its resorptive effects.

引用

页码：692 / 694

页数：3

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