Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical

被引：24

作者：

Dobbs, CM

Haskins, K

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 166卷 / 04期

关键词：

D O I：

10.4049/jimmunol.166.4.2495

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been widely assumed that T cells from TCR-transgenic (Tg) mice better represent the behavior of T cells from normal mice than do in vitro cultures of T cell clones. We have found that autoreactive T cells arising in the presumably more physiological environment of the BDC-2.5 TCR-Tg mouse, despite being apparently "naive" in surface phenotype, are highly activated functionally and do not resemble CD4(+) T cells from a spontaneously diabetic nonobese diabetic (NOD) mouse or the NOD-derived, diabetogenic CD4+ T cell clone of origin, BDC-2.5. Our results suggest that autoreactive T cells cloned from the spontaneously diabetic NOD mouse more closely resemble effector T cells arising during the natural disease process. The Journal of Immunology, 2001, 166: 2495-2504.

引用

页码：2495 / 2504

页数：10

共 63 条

[1]

Abitorabi MA, 1996, J IMMUNOL, V156, P3111

[2]

Ahmadzadeh M, 1999, J IMMUNOL, V163, P3053

[3] IL-1α, IL-1β, and IFN-γ mark β cells for Fas-dependent destruction by diabetogenic CD4+ T lymphocytes [J].