PDLLA/β-TCP/HA/CHS/NGF Sustained-release Conduits for Peripheral Nerve Regeneration

被引：5
作者：
Yan Xiumei [1 ]
Wang Jing [2 ]
He Qundi [3 ]
Xu Haixing [1 ]
Tao Junyan [4 ]
Koral, Kelly [4 ]
Li Kebi [1 ]
Xu Jingyi [1 ]
Wen Jing [1 ]
Huang Zhijun [1 ]
Xi Peihu [1 ]
机构：
[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Dept Pharmaceut Engn, Wuhan 430070, Peoples R China
[2] China Resources Sanjiu Med & Pharmaceut Co Ltd, Shenzhen 518029, Peoples R China
[3] Wuhan Mafangshan Middle Sch, Wuhan 430070, Peoples R China
[4] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA
来源：
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION | 2021年 / 36卷 / 04期
关键词：
sustained-release; composite nerve conduits; peripheral nerve regeneration; GROWTH-FACTOR; COMPOSITE;
D O I：
10.1007/s11595-021-2450-6
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Using nerve guide conduits (NGCs) to promote the regeneration of PNI is a feasible alternative to autograft. Compared with NGCs made of single material, composite NGCs have a greater development prospect. Our previous research has confirmed that poly(D, L-lactic acid)/beta-tricalcium phosphate/hyaluronic acid/chitosan/nerve growth factor (PDLLA/beta-TCP/HA/CHS/NGF) NGCs have excellent physical and chemical properties, which can slowly release NGF and support cell adhesion and proliferation. In this study, PDLLA/beta-TCP/HA/CHS/NGF NGCs were prepared and used to bridge a 10 mm sciatic nerve defect in 200-250 g Sprague-Dawley (SD) rat to verify the performance of the NGCs in vivo. Substantial improvements in nerve regeneration were observed after using the PDLLA/beta-TCP/HA/CHS/NGF NGCs based on gross post-operation observation, triceps wet weight analysis and nerve histological assessment. In vivo studies illustrate that the PDLLA/beta-TCP/HA/CHS/NGF sustained-release NGCs can effectively promote peripheral nerve regeneration, and the effect is similar to that of autograft.
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收藏
页码：600 / 606
页数：7
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