Dietary daidzein, but not genistein, has a hypocholesterolemic effect in non-ovariectomized and ovariectomized female Sprague-Dawley rats on a cholesterol-free diet

被引：16

作者：

Bhattarai, Keshab ^{[1
]}

Adhikari, Sudhashree ^{[1
]}

Fujitani, Mina ^{[1
,2
]}

Kishida, Taro ^{[1
,2
]}

机构：

[1] Ehime Univ, United Grad Sch Agr Sci, Matsuyama, Ehime, Japan

[2] Ehime Univ, Grad Sch Agr, Matsuyama, Ehime, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 09期

关键词：

daidzein; hypocholesterolemic effect; ovariectomy; gene expression; ApoB; GOLDEN SYRIAN-HAMSTERS; HMG-COA REDUCTASE; SOY PROTEIN; SERUM-CHOLESTEROL; PLASMA-CHOLESTEROL; NUCLEAR RECEPTORS; ACID SYNTHESIS; BILE-ACIDS; ISOFLAVONES; ATHEROSCLEROSIS;

D O I：

10.1080/09168451.2017.1350562

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We compared the effects of two major isoflavones, daidzein and genistein, on lipid metabolism in rats. Daidzein (150mg/kg diet), genistein (150mg/kg diet), daidzein and genistein (1:1, 300mg/kg diet), or control diets were fed to 4 groups of 6-week-old ovariectomized (Ovx) and non-Ovx Sprague Dawley rats for 4weeks. Dietary daidzein, but not genistein, reduced serum and hepatic total cholesterol levels significantly relative to that by the control group, regardless of whether the rats had undergone ovariectomy. Genistein did not exhibit any physiological effects on lipid levels, but did affect genes involved in cholesterol metabolism. These results indicate that daidzein and genistein may influence lipid regulation via differing modes of action.

引用

页码：1805 / 1813

页数：9

共 43 条

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