A preoperative prognostic nutritional index is a prognostic indicator in oral squamous cell carcinoma patients undergoing radical surgery

被引：17
作者：
Watabe, Y. [1 ]
Aoki, K. [2 ]
Ichikawa, H. [3 ]
Matsuzaki, H. [2 ]
Ito, A. [3 ]
Tanaka, J. I. [3 ]
Kamiyama, I. [1 ]
Shigematsu, S. [1 ]
机构：
[1] Tokyo Metropolitan Tama Med Ctr, Dept Dent & Oral Surg, 2-8-29 Musashidai, Fuchu, Tokyo 1838524, Japan
[2] Tokyo Metropolitan Bokutoh Hosp, Dept Dent & Oral Surg, Sumida Ku, Tokyo, Japan
[3] Tokyo Metropolitan Otsuka Hosp, Dept Stomatol, Toshima Ku, Tokyo, Japan
来源：
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2021年 / 50卷 / 11期
关键词：
Nutrition assessment; mouth neoplasms; inflammation; prognosis; biomarkers; DEPENDENT ROC CURVES; CANCER; SURVIVAL; INFLAMMATION; LYMPHOCYTES; PREDICTS; HEAD;
D O I：
10.1016/j.ijom.2021.01.009
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The purpose of this study was to investigate the prognostic value of prognostic nutritional index (PNI) in oral squamous cell carcinoma (OSCC) patients and to undertake a comparative evaluation of the prognostic value of comparing PNI, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in terms of prognostic utility. A retrospective study was conducted involving 203 consecutive patients with OSCC who were treated with radical surgery with curative intent. The PNI and systemic inflammatory response were developed, and their prognostic utility was evaluated. Kaplan-Meier curve analysis and log-rank testing showed that PNI (P< 0.001), NLR (P=0.011), PLR (P=0.013), and LMR (P=0.014) were significantly associated with overall survival. Multivariate analysis identified PNI as an independent prognostic factor for OSCC patients (P=0.029). In time-dependent receiver operating characteristic curve analysis, PNI was continuously superior to that of NLR, PLR, and LMR. In conclusion, this study suggested that PNI offered an independent prognostic biomarker in OSCC patients undergoing radical surgery. However, this study was small and retrospective, thus further investigations are needed to clarify the utility of PNI for tailor-made treatments in clinical settings.
引用
收藏
页码：1413 / 1421
页数：9
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