The central role of Sertoli cells in spermatogenesis

被引：711

作者：

Griswold, MD ^{[1
]}

机构：

[1] Washington State Univ, Dept Biochem & Biophys, Pullman, WA 99164 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1998年 / 9卷 / 04期

关键词：

FSH; germ cells; Sertoli cells; testosterone; transferrin;

D O I：

10.1006/scdb.1998.0203

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by controlling the environment milieu within the seminiferous tubules. The regulation of spermatogenesis by FSH and testosterone occurs by the action of these hormones on the Sertoli cells. While the action of testosterone is necessary for spermatogenesis, the action of FSH minimally serves to promote spermatogenic output by increasing the number of Sertoli cells.

引用

页码：411 / 416

页数：6

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