Virtual screening and further development of novel ALK inhibitors

被引：13

作者：

Okamoto, Masako ^{[1
,2
]}

Kojima, Hirotatsu ^{[1
]}

Saito, Nae ^{[1
]}

Okabe, Takayoshi ^{[1
]}

Masuda, Yoshiaki ^{[1
,2
]}

Furuya, Toshio ^{[1
,2
]}

Nagano, Tetsuo ^{[1
,3
]}

机构：

[1] Univ Tokyo, Chem Biol Res Initiat, Bunkyo Ku, Tokyo 1130033, Japan

[2] PharmaDesign Inc, Div Res & Dev, Drug Discovery Dept, Chuo Ku, Tokyo 1040032, Japan

[3] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 10期

关键词：

ALK; anaplastic lymphoma kinase; NSCLC; non-small-cell lung cancer; Virtual screening; Chemical library; ANAPLASTIC LYMPHOMA KINASE; CRYSTAL-STRUCTURE; IDENTIFICATION; COMPLEX; FUSION; GENE; NPM;

D O I：

10.1016/j.bmc.2011.04.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anaplastic lymphoma kinase (ALK) has been in the spotlight in recent years as a promising new target for therapy of non-small-cell lung cancer (NSCLC). Since the identification of the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion gene in some NSCLC patients was reported in 2007, various research groups have been seeking ALK inhibitors. Above all, crizotinib (PF-02341066) has been under clinical trial, and its therapeutic efficacy of inhibiting ALK in NSCLC has been reported. Among anticancer drugs, drug resistance appears frequently necessitating various kinds of inhibitors. We identified novel ALK inhibitors by virtual screening from the public chemical library collected by the Chemical Biology Research Initiative (CBRI) at the University of Tokyo, and inhibitors that are more potent were developed. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3086 / 3095

页数：10

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