Stannylation approach to the synthesis of 2′- and 3′-substituted analogues of 2′,3′-didehydro-2′,3′-dideoxynucleosides

被引：0
|
作者：
Kumamoto, H [1 ]
Onuma, S [1 ]
Tanaka, H [1 ]
机构：
[1] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo 1428555, Japan
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期
关键词：
2; 3; '-didehydro-2; 3 '-dideoxy nucleoside; stannylation; anionic migration; desulfonylative-stannylation; sulfoxide-metal exchange;
D O I：
10.1081/NCN-120022630
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three methods are described for the introduction of a tributylstannyl group to the sp(2)-carbon of 2,3-didehydro-2',3'-dideoxy nucleosides (d44Ns). The resulting stannylated products serve as versatile intermediates for the synthesis of d4Ns having various types of carbon-substituent.
引用
收藏
页码：767 / 769
页数：3
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