SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study

被引：11

作者：

Eriksen, Alexandra R. Rothlin ^{[1
,2
,3
]}

Fogh, Kamille ^{[1
,2
,3
]}

Hasselbalch, Rasmus B. ^{[1
,2
,3
]}

Bundgaard, Henning ^{[3
,4
]}

Nielsen, Susanne D. ^{[3
,5
]}

Jorgensen, Charlotte S. ^{[6
]}

Scharff, Bibi F. S. S. ^{[3
,7
]}

Erikstrup, Christian ^{[8
,9
]}

Saekmose, Susanne G. ^{[3
,10
]}

Holm, Dorte K. ^{[11
,12
]}

Aagaard, Bitten ^{[13
]}

Kristensen, Jonas H. ^{[1
,2
]}

Bodker, Cecilie A. ^{[1
,2
]}

Norsk, Jakob B. ^{[1
,2
]}

Nielsen, Pernille B. ^{[1
,2
]}

ostergaard, Lars ^{[14
]}

Ellermann-Eriksen, Svend ^{[8
,9
]}

Andersen, Berit ^{[15
]}

Nielsen, Henrik ^{[16
,17
]}

Johansen, Isik S. ^{[12
,18
]}

Wiese, Lothar ^{[19
]}

Simonsen, Lone ^{[20
]}

Fischer, Thea K. ^{[21
,22
]}

Folke, Fredrik ^{[3
,23
]}

Lippert, Freddy ^{[3
,23
]}

Ostrowski, Sisse R. ^{[7
]}

Ethelberg, Steen ^{[6
]}

Koch, Anders ^{[6
]}

Vangsted, Anne-Marie ^{[6
]}

Krause, Tyra ^{[6
]}

Fomsgaard, Anders ^{[6
]}

Nielsen, Claus ^{[6
]}

Ullum, Henrik ^{[6
]}

Skov, Robert ^{[6
]}

Iversen, Kasper ^{[1
,2
]}

机构：

[1] Copenhagen Univ Hosp, Dept Cardiol, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Denmark

[2] Copenhagen Univ Hosp, Dept Emergency Med, Herlev, Denmark

[3] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[4] Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark

[5] Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis, Copenhagen, Denmark

[6] Statens Serum Inst, Copenhagen, Denmark

[7] Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark

[8] Aarhus Univ Hosp, Dept Clin Microbiol, Aarhus, Denmark

[9] Aarhus Univ, Dept Clin Med, Aarhus, Denmark

[10] Zealand Univ Hosp, Dept Clin Immunol, Koge, Denmark

[11] Odense Univ Hosp, Dept Clin Immunol, Odense, Denmark

[12] Univ Southern Denmark, Dept Res Med, Odense, Denmark

[13] Aalborg Univ Hosp, Dept Clin Immunol, Aalborg, Denmark

[14] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark

[15] Univ Res Clin Canc Screening, Randers Reg Hosp, Randers, Denmark

[16] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark

[17] Aalborg Univ, Dept Clin Med, Odense, Denmark

[18] Odense Univ Hosp, Dept Infect Dis, Odense, Denmark

[19] Zealand Univ Hosp, Dept Infect Dis, Roskilde, Denmark

[20] Univ Roskilde, Dept Sci & Environm, Roskilde, Denmark

[21] North Zealand Hosp, Dept Clin Res, Hillerod, Denmark

[22] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[23] Copenhagen Emergency Med Serv, Copenhagen, Denmark

来源：

BMC PUBLIC HEALTH | 2022年 / 22卷 / 01期

关键词：

SUBSTANCE USE DISORDERS; HIGH-INCOME COUNTRIES; SEX WORKERS; HEALTH; COVID-19; ENGLAND; RISK;

D O I：

10.1186/s12889-022-13642-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with "Severe acute respiratory syndrome coronavirus 2 '' (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denmark. Design and methods: In November 2020, we conducted a nationwide cross-sectional seroprevalence study among PEH and shelter workers at 21 recruitment sites in Denmark. The assessment included a point-of-care test for antibodies against SARS-CoV-2, followed by a questionnaire. The seroprevalence was compared to that of geographically matched blood donors considered as a proxy for the background population, tested using a total Ig ELISA assay. Results: We included 827 participants in the study, of whom 819 provided their SARS-CoV-2 antibody results. Of those, 628 were PEH (median age 50.8 (IQR 40.9-59.1) years, 35.5% female) and 191 were shelter workers (median age 46.6 (IQR 36.1-55.0) years and 74.5% female). The overall seroprevalence was 6.7% and was similar among PEH and shelter workers (6.8% vs 6.3%, p= 0.87); and 12.2% among all participants who engaged in sex work. The overall participant seroprevalence was significantly higher than that of the background population (2.9%, p< 0.001). When combining all participants who reported sex work or were recruited at designated safe havens, we found a significantly increased risk of seropositivity compared to other participants (OR 2.23, 95%CI 1.06-4.43, p= 0.02). Seropositive and seronegative participants reported a similar presence of at least one SARS-CoV-2 associated symptom (49% and 54%, respectively). Interpretations: The prevalence of SARS-CoV-2 antibodies was more than twice as high among PEH and associated shelter workers, compared to the background population. These results could be taken into consideration when deciding in which phase PEH are eligible for a vaccine, as part of the Danish national SARS-CoV-2 vaccination program rollout.

引用

页数：13

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