Replication of recently described type 2 diabetes gene variants in a South Indian population

被引：33

作者：

Chidambaram, Manickam

Radha, Venkatesan ^{[1
]}

Mohan, Viswanathan

机构：

[1] ICMR Adv Ctr Genom Diabet, Madras Diabet Res Fdn, Women Soc, Dept Mol Genet, Madras 603103, Tamil Nadu, India

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2010年 / 59卷 / 12期

关键词：

GENOME-WIDE ASSOCIATION; IMPAIRED GLUCOSE-TOLERANCE; URBAN-RURAL EPIDEMIOLOGY; RISK LOCI; MEXICAN-AMERICANS; ASIAN-INDIANS; CDKAL1; SUSCEPTIBILITY; OBESITY; TCF7L2;

D O I：

10.1016/j.metabol.2010.04.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent genomewide association studies have identified several new gene variants associated with type 2 diabetes mellitus (T2D) mostly in European populations. These need to be replicated in other populations. We studied 926 unrelated T2D and 812 normal glucose-tolerant subjects randomly selected from the Chennai Urban Rural Epidemiology Study in Southern India. A total of 45 single nucleotide polymorphisms (SNPs) from 15 genes and 13 unannotated loci identified from recent genomewide association T2D studies were genotyped. Only 6 of 45 SNPs studied were replicated in this South Indian population. Three SNPs-rs7756992 (P=.007), rs7754840 (P=.015), and rs6931514 (P=.029)-of the CDKAL1, rs7020996 (P=.003) of the CDKN2A/B gene, rs7923837 (P=.038) of the HHEX gene, and rs12056034 (P=.033) of the BAZ1B gene were associated with T2D in our population. Large-scale studies are needed in our population to validate our findings. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1760 / 1766

页数：7

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