Effects of acute trichloroacetic acid treatment on the in-vivo activity of glucose 6-phosphate dehydrogenase and carbonic anhydrase in various tissues of rats

被引：0

作者：

Celik, I ^{[1
]}

Demir, H

机构：

[1] Yuzuncu Yil Univ, Fac Arts & Sci, Dept Biol, TR-65080 Van, Turkey

[2] Yuzuncu Yil Univ, Fac Arts & Sci, Dept Chem, TR-65080 Van, Turkey

来源：

FRESENIUS ENVIRONMENTAL BULLETIN | 2005年 / 14卷 / 04期

关键词：

trichloroacetic acid; carbonic anhydrase; glucose6-phosphate dehydrogenase; rats;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study was carried out to investigate possible trichloroacetic acid (TCA) effects on the activity of glucose 6-phosphate dehydrogenase (G6PD) and carbonic anhydrase (CA) in muscle and liver tissues of rats under laboratory conditions. Five Sprague-Dawley albino rats were used for experiments, and 200 mg TCA/kg body weight was administered intraperitoneally. Tissue G6PD and CA activities in muscle and liver of rats were determined six hours after treatment. According to the results, the TCA treatment caused significant decrease in muscle and liver G6PD, but no significant difference in liver CA level was observed, in comparison to control rats. Therefore, it is conceivable that TCA is a toxicant like other pesticides, and is primarily interacting with liver and muscle tissue cells.

引用

页码：256 / 258

页数：3

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