Role of histone acetylation in cell physiology and diseases: An update

被引：58

作者：

Khan, Shahper N. ^{[1
]}

Khan, Asad U. ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Interdisciplinary Biotechnol Unit, Aligarh 202002, Uttar Pradesh, India

来源：

CLINICA CHIMICA ACTA | 2010年 / 411卷 / 19-20期

关键词：

Histone acetylation; Epigenetics; Diseases; Cell physiology; CREB-BINDING PROTEIN; CRYSTAL-STRUCTURE; DEACETYLASE INHIBITOR; IN-VIVO; TRANSCRIPTIONAL REPRESSION; ACETYLTRANSFERASE ACTIVITY; COVALENT MODIFICATIONS; RB-RAF-1; INTERACTION; YEAST GCN5P; DNA-BINDING;

D O I：

10.1016/j.cca.2010.06.020

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Although the role of histone acetylation in gene regulation has been the subject of many reviews, their impact on cell physiology and pathological states of proliferation, differentiation and genome stability in eukaryotic cells remain to be elucidated. Therefore, this review will discuss the molecular, physiological and biochemical aspects of histone acetylation and focus on the interplay of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in different disease states. Current treatment strategies are mostly limited to enzyme inhibitors, though potential lies in targeting other imperative chromatin remodeling factors involved in gene regulation. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1401 / 1411

页数：11

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