Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics

被引：7

作者：

Chen, Bing ^{[1
,2
]}

Chu, Chengchao ^{[2
]}

Ren, En ^{[2
]}

Lin, Huirong ^{[2
]}

Zhang, Yang ^{[2
]}

Wang, Peiyu ^{[2
]}

Yao, Hong ^{[1
]}

Liu, Ailin ^{[1
]}

Liu, Gang ^{[2
]}

Lin, Xinhua ^{[1
]}

机构：

[1] Fujian Med Univ, Nano Med Technol Res Inst, Sch Pharm, Educ Dept Fujian Prov,Key Lab Nanomed Technol, Fuzhou, Peoples R China

[2] Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen, Peoples R China

来源：

FRONTIERS IN CHEMISTRY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

supramolecular therapeutic systems; metal-coordination-assisted; in vivo self-assembly; tumor microenvironment; personalized medicine;

D O I：

10.3389/fchem.2022.870769

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal-ion-based self-assembly supramolecular theranostics exhibit excellent performance in biomedical applications owing to their potential superiorities for simultaneous precise diagnosis, targeted drug delivery, and monitoring the response to therapy in real-time. Specially, the rational designed systems could achieve specific in vivo self-assembly through complexation or ionic interaction to improve tissue-specific accumulation, penetration, and cell internalization, thereby reducing toxicities of drugs in diagnostics and therapy. Furthermore, such imaging traceable nanosystems could provide real-timely information of drug accumulation and therapeutic effects in a non-invasive and safe manner. Herein, the article highlights the recent prominent applications based on the metal ions self-assembly in cancer treatment. This strategy may open up new research directions to develop novel drug delivery systems for cancer theranostics.

引用

页数：5

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