Nitroimidazoles and hypoxia imaging:: Synthesis of three Technetium-99m complexes bearing a nitroimidazole group:: Biological results

被引：31

作者：

Riché, F

d'Hardemare, AD

Sèpe, S

Riou, L

Fagret, D

Vidal, M

机构：

[1] Univ Grenoble 1, Etud Dynam & Struct Select Lab, UMR 5616, F-38041 Grenoble 9, France

[2] Univ Grenoble 1, Lab Etud Radiopharmaceut, INSERM, F-38700 La Tronche, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)00593-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several Tc-99m complexes were synthesized, substituted with a nitroimidazole group, in order to visualize hypoxic tissues. The complexes were tested on rats (isolated hearts) and showed no significant uptake under hypoxic conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：71 / 74

页数：4

共 17 条

[1]

BERNE RM, 1993, PHYSL, P292

[2] SYNTHESIS OF AN (IODOVINYL)MISONIDAZOLE DERIVATIVE FOR HYPOXIA IMAGING [J].