Synthesis and structure confirmation of 7-ester-8-aminomethylene-substituted baicalein derivatives

被引：1

作者：

Mou, Jiajia ^{[1
]}

Wang, Qiang ^{[2
]}

Deng, Yanru ^{[1
]}

Chen, Danghui ^{[1
]}

Qiu, Shuang ^{[1
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Dept Med Chem, Hlth Ind Pk, Tianjin 301617, Peoples R China

[2] South Cent Univ Nationalities, Coll Pharm, Wuhan, Peoples R China

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2021年 / 68卷 / 09期

基金：

中国国家自然科学基金;

关键词：

baicalein derivatives; esterification reaction; Mannich reaction; strontium chloride identification reaction; BIOLOGICAL EVALUATION; CELL-CYCLE; FLAVONOIDS; GROWTH;

D O I：

10.1002/jccs.202100194

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Twelve baicalein derivatives, derivatized with 7-ester and 8-aminomethylene groups, were synthesized as cyclin-dependent kinase 1 (CDK1) inhibitors, by the addition of one of four secondary amines to C-8, using the Mannich reaction, followed by mono-esterification with one of three carboxylic acids. Analysis by H-1-, C-13-NMR, and HMBC spectra, as well as a chemical test, confirmed that the esterification occurred at the 7-phenolic hydroxyl position of baicalein but not at the 5- or 6-positions.

引用

页码：1598 / 1603

页数：6

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