ANTI-VIRAL TETRIS: Modulation of the Innate Anti-Viral Immune Response by A20

被引：0

作者：

Arguello, Meztli ^{[1
,2
]}

Paz, Suzanne ^{[1
,2
]}

Ferran, Christiane ^{[3
]}

Moll, Herwig P. ^{[3
]}

Hiscott, John ^{[1
,2
,4
]}

机构：

[1] McGill Univ, Dept Microbiol, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3A 2T5, Canada

[2] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Dept Immunol, Montreal, PQ H3T 1E2, Canada

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Vasc & Endovasc Surg,Ctr Vasc Biol Res, Boston, MA 02215 USA

[4] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA

来源：

MULTIPLE THERAPEUTIC TARGETS OF A20 | 2014年 / 809卷

基金：

加拿大健康研究院;

关键词：

NF-KAPPA-B; UNANCHORED POLYUBIQUITIN CHAINS; I INTERFERON INDUCTION; RNA VIRUS-INFECTION; E3 UBIQUITIN LIGASE; TOLL-LIKE RECEPTORS; FINGER PROTEIN A20; HEPATITIS-C VIRUS; INDUCIBLE GENE-I; RIG-I;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The A20 protein has emerged as an important negative regulator of Toll like receptor (TLR) andretinoic acid-inducible gene 1 (RIG-I)-mediated anti-viral signaling, A20 functions both as a RING-type E3 ubiquitin ligase and as a de-ubiquitinating enzyme. Nuclear factor kappa B (NF-kappa B) and interferon regulatory factor (TRF) pathways are targeted by A20 through mechanisms that appear to be both overlapping and distinct, resulting in the downregulation of interferon alpha/beta (IFN alpha/beta) production. This review specifically details the impact of A20 on the cytosolic RTG-TIMDAS pathway, a process that is less understood than that of NF-kappa B but is essential for the regulation of the innate immune response to viral infection.

引用

页码：49 / 64

页数：16

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