Smallpox Vaccine Safety Is Dependent on T Cells and Not B Cells

被引：55

作者：

Gordon, Shari N. ^{[1
]}

Cecchinato, Valentina ^{[1
]}

Andresen, Vibeke ^{[1
]}

Heraud, Jean-Michel ^{[7
]}

Hryniewicz, Anna ^{[1
]}

Parks, Robyn Washington ^{[1
]}

Venzon, David ^{[2
]}

Chung, Hye-kyung ^{[5
]}

Karpova, Tatiana ^{[3
]}

McNally, James ^{[4
]}

Silvera, Peter ^{[4
]}

Reimann, Keith A. ^{[6
]}

Matsui, Hajime ^{[8
]}

Kanehara, Tomomi ^{[8
]}

Shinmura, Yasuhiko ^{[8
]}

Yokote, Hiroyuki ^{[8
]}

Franchini, Genoveffa ^{[1
]}

机构：

[1] Anim Models & Retroviral Vaccines Sect, Bethesda, MD 20892 USA

[2] NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA

[3] Lab Receptor Biol Gene Express & Metab, Fluorescence Imaging Facil, Bethesda, MD USA

[4] So Res Inst, Frederick, MD USA

[5] Adv Bioscience Labs, Kensington, MD USA

[6] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Viral Pathogenesis,Dept Med, Boston, MA 02215 USA

[7] Inst Pasteur Madagascar, World Hlth Org Natl Influenza Lab, Antananarivo, Madagascar

[8] Chemoserotherapeut Res Inst KAKETSUKEN, Kumamoto, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 08期

关键词：

VIRUS SIVMAC251 INFECTION; ATOPIC-DERMATITIS; PROTECTS MONKEYS; COMPLICATIONS; ACAM2000; EXPRESSION; CD4(+); TISSUE; LC16M8; MODEL;

D O I：

10.1093/infdis/jiq162

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The licensed smallpox vaccine, ACAM2000, is a cell culture derivative of Dryvax. Both ACAM2000 and Dryvax are administered by skin scarification and can cause progressive vaccinia, with skin lesions that disseminate to distal sites. We have investigated the immunologic basis of the containment of vaccinia in the skin with the goal to identify safer vaccines for smallpox. Macaques were depleted systemically of T or B cells and vaccinated with either Dryvax or an attenuated vaccinia vaccine, LC16m8. B cell depletion did not affect the size of skin lesions induced by either vaccine. However, while depletion of both CD4(+) and CD8(+) T cells had no adverse effects on LC16m8-vaccinated animals, it caused progressive vaccinia in macaques immunized with Dryvax. As both Dryvax and LC16m8 vaccines protect healthy macaques from a lethal monkeypox intravenous challenge, our data identify LC16m8 as a safer and effective alternative to ACAM2000 and Dryvax vaccines for immunocompromised individuals.

引用

页码：1043 / 1053

页数：11

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