Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities

被引：71
|
作者：
Li, Jing [1 ]
Huang, Wenlong [1 ]
Zhang, Huibin [1 ]
Wang, Xinyang [2 ]
Zhou, Huiping [3 ]
机构：
[1] China Pharmaceut Univ, Coll Pharm, Ctr Drug Discovery, Nanjing 210009, Peoples R China
[2] Nantong Univ, Coll Med, Nantong 226000, Peoples R China
[3] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 24期
关键词：
TNF-alpha; IL-6; inhibitors; andrographolide; derivatives; synthesis;
D O I：
10.1016/j.bmcl.2007.10.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on TNF-alpha and IL-6 secretion in mouse macrophages were also evaluated. Most of the tested compounds showed inhibitory effects, and the compounds with the structure of 12-hydroxy-14-dehydroandrographolide showed better inhibitory activity than the compounds with the structure of isoandrographolide. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：6891 / 6894
页数：4
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