P-selectin induction of tissue factor biosynthesis and expression

被引：0

作者：

Furie, B

Furie, BC

机构：

[1] TUFTS UNIV,SCH MED,DEPT MED,BOSTON,MA 02111

[2] TUFTS UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02111

来源：

HAEMOSTASIS | 1996年 / 26卷

关键词：

P-selectin; cell adhesion; signal transduction;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P-selectin on activated platelets and stimulated endothelial cells mediates cell adhesion with monocytes and neutrophils. Since activated platelets induce tissue factor on monocytes, we examined the effect of P-selectin on this activity. Chinese hamster ovary cells expressing P-selectin stimulated tissue factor activity in purified monocytes whereas untransfected Chinese hamster ovary cells and CHO cells expressing E-selectin did not. Anti-P-selectin antibodies inhibited these effects. Incubation of CHO:P-selectin with monocytes stimulates tissue factor mRNA development and the expression of tissue factor antigen on the monocyte surface. These results indicate that P-selectin upregulates the expression of tissue factor on monocytes.

引用

页码：60 / 65

页数：6

共 40 条

[1]

BACH R, 1981, J BIOL CHEM, V256, P8324

[2] A PLATELET ALPHA GRANULE MEMBRANE-PROTEIN THAT IS ASSOCIATED WITH THE PLASMA-MEMBRANE AFTER ACTIVATION - CHARACTERIZATION AND SUBCELLULAR-LOCALIZATION OF PLATELET ACTIVATION-DEPENDENT GRANULE-EXTERNAL MEMBRANE-PROTEIN [J].