Hypothesis - Pulse pressure and human longevity

被引：43
作者：
Aviv, A [1 ]
机构：
[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Hypertens Res Ctr, Newark, NJ 07103 USA
来源：
HYPERTENSION | 2001年 / 37卷 / 04期
关键词：
aging; hypertension; essential; telomere; reactive oxygen species; menopause; evolution; genetics;
D O I：
10.1161/01.HYP.37.4.1060
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
In exploration of the association between pulse pressure and longevity in humans, 3 hypotheses are briefly discussed: the fetal origin hypothesis, antagonistic pleiotropy, and the telomere hypothesis of cellular aging. The implications of these hypotheses serve to draw a critical distinction between biologic age (aging) and chronological age and, thereby, offer an answer to a question that presently matters most in the field of hypertension: Why has it been so difficult to disentangle the genetic components of essential hypertension and to identify the variant genes responsible for elevated blood pressure in a large segment of the human population?
引用
收藏
页码：1060 / 1066
页数：7
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